عنوان مقاله [English]
Application of new spectrophotometric methods for simultaneous determination of ascorbic acid and acetylsalicylic acid in binary mixtures
Ghadamali Bagherian, Raziyeh Rahdari, Mansour Arab Chamjangali, Motahare Ashrafi
Collge of Chemistry, Shahrood University of Technology, Shahrood, P.O. Box 36155-316, Iran.
Received: ……. Received in revised form: ……. Accepted: ………..
In this work, application of the new and cost-effective spectrophotometric methods including the extended ratio subtraction method (EXRSM) and the ratio difference (RD) method for the simultaneous determination of ascorbic acid and acetylsalicylic acid in binary mixtures without using a physical separation were studied. The factors affecting the sensitivity of the methods were investigated and optimized. Under the optimal conditions, the linear ranges for ascorbic acid and acetylsalicylic acid in these methods were 2-30 mg/L and 10-30 mg/L, respectively. The detection limit for ascorbic acid was 0.435 in EXRSM and 0.115 mg/L in RD, whereas the value of this parameter for acetylsalicylic acid was 1.44 in EXRSM and 0.363 mg/L in RD. EXRSM was used for the simultaneous determination of ascorbic acid and acetylsalicylic acid in the urban water and synthetic tablet samples and the RD method was used for the synthetic tablet samples with a satisfactory accuracy and precision.
Keywords: Acetylsalicylic acid, Ascorbic acid, Extended ratio subtraction method, Ratio difference method.