Iranian Journal of Chemistry

Iranian Journal of Chemistry

Modified graphene oxide for micro-solid phase extraction of ciprofloxacin from seawater employing chemometrics optimization

Document Type : Original Article

Authors
Fateme Keykha 1
Sayyed Hossein Hashemi 1
Massoud Kaykhaii 2
Ahmad Jamali Keikha 1
1 Chabahar Maritime University
2 Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
10.22036/cr.2022.320353.1166
Abstract
A novel graphene oxide/ zinc oxide nano composite was synthesized and employed for simple and sensitive pipette tip based micro solid phase extraction of ciprofloxacin from seawater and human blood plasma samples following by their determination by spectrophotometry. Several parameters affecting the suggested protocol were optimized, namely type and volume of eluent, amount of sorbent, sample volume, ionic strength of sample solution, and number of cycles of extraction and elution. The optimizations were performed by both response surface methodology and one variable at a time techniques. Analytical figures of merit were achieved as: detection limit; 0.17 µg/L, linear calibration curve in the range of 1.0-200.0 µg/L; and reproducibility (as RSD%) better than 5.6. Results for the application of the technique in seawater and human blood plasma showed that this analysis method can be applied for the determination of the analyte in complex real samples such as seawater and human successfully.

Graphical Abstract

Modified graphene oxide for micro-solid phase extraction of ciprofloxacin from seawater employing chemometrics optimization
Keywords
Ciprofloxacin
Graphene oxide/zinc oxide nanocomposite
Human blood plasma
Pipette tip micro solid phase extraction
Seawater
Subjects
  1. M. Varak Neshin, M. Ebrahimi, J. Anal. Chem. 13, 1 (2018)
  2. F. Vella, J. Busuttil, N. S. Bartolo, C. Sammut, V. Ferrito, A. Serracino-Inglott, L.M. Azzopardi, G. LaFerla, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 989, 80 (2015)
  3. N. M. Kassab, A. K. Singh, E. R. M. Kedor-Hackmam, M. I. R. M. Santoro, Rev. Bras. Cienc. 41, 507 (2005)
  4. Z. Lian, J. Wang, Marine Poll. Bull. 111, 411 (2016)
  5. S. H. Hashemi, M. Ziyaadini, M. Kaykhaii, A. Jamali Keikha, N. Naruie, J. Sep. Sci. 43, 505 (2019a)
  6. A. Speltini, M. Sturini, F. Maraschi, L. Consoli, A. Zeffiro, A. Profumo, J. Chromatogr. A 1379, 9 (2015)
  7. K. Rekha, J. Santosh, T. Dilshadbee, T. Ashpak, Int. J. Adv. Sci. Res. Rev. 1, 137 (2015)
  8. S. S. Wu, C. Y. Chein, Y. H. Wen, J. Chromatogr. Sci. 46, 490 (2008)
  9. M. K. Khan, M. F. Khan, Pak. J. Pharm. Sci. 21, 299 (2008)
  10. S. Watabe, Y. Yokoyama, K. Nakazawa, K. Shinozaki, R. Hiraoka, K. Takeshita, Y. Suzuki, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 878, 1555 (2010)
  11. O. R. Idowu, J. O. Peggins, J. Pharm. Biomed. Anal. 35, 143 (2004)
  12. K.H. Bannefeld, H. Stass, G. Blaschke, J. Chromatogr. B: Biomed. Sci. Appl. 692, 453 (1997)
  13. C. Grondin, W. Zhao, M. Fakhoury, E. Jacqz-Aigrain, Biomed. Chromatogr. 25, 827 (2011)
  14. G. Chen, Q. Li, J. Agric. Food Chem. 61, 98 (2013)
  15. W. A. W. Ibrahim, H. R. Nodeh, M. M. Sanagi, Crit. Rev. Anal. Chem. 46, 267 (2016)
  16. S. H. Hashemi, M. Kaykhaii, A. Jamali Keikha, A. Parkaz, Anal. Methods 10, 5707 (2018)
  17. N. Zhang, B. Hu, Anal. Chim. Acta 723, 54 (2012)
  18. K. Rekha, J. Santosh, T. Dilshadbee, T. Ashpak, Int. J. Adv. Sci. Res. Rev. 1, 137 (2015)
  19. M. I. Pascual-Reguera, G. P. Parras, A. M. Dı́az, Microchem. J. 77, 79 (2004)
  20. S. N. Muchohi, N. Thuo, J. Karisa, A. Muturi, G. O. Kokwaro, K. Maitland, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 879, 146 (2011)
  21. S. H. Hashemi, F. Keykha, Anal. Methods 11, 5405 (2019)

 

  • Receive Date 19 December 2021
  • Revise Date 18 June 2022
  • Accept Date 23 June 2022