Fast and simple measurement of vitamin B12 by using nitrogen and sulfur co doped carbon quantum dots

Document Type : Original Article

Authors

1 Analyical chemisry, Faculty of chemistry, Urmia University

2 Faculty of chemistry , Urmia university

3 Malek Ashtar University of Technology

10.22036/cr.2020.207748.1097

Abstract

Here, a green, low-cost, simple method for the production of Nitrogen-Sulphur-co doped carbon quantum dots via a one-step hydrothermal .Pomegranate juice was used as a source of carbon while cystamine as a source of sulfur and nitrogen. The carbon quantum dots were characterized by using X transmission electron microscopy (TEM), and Fourier Transform Infrared Spectroscopy (FT-IR ). The carbon quantum dots were used as a fluorescence sensor for selective and sensitive determination of vitamin B 12. Briefly, the fluorescence intensity of carbon-doped was quenched in the presence of vitamin B12. The decrease in fluorescence intensity allowed for the analysis of vitamin B12 with satisfactory limit of detection and linear dynamic rang. The Stern- Valmer plot shows a linear relationship (R2 = 0.99) between F0 / F and vitamin B12 concentration in the range of 0 to 110 μM. The detection limit (LOD) of M was 8.2 10-8. Also, to evaluate the ability of this method for the analysis of real samples, vitamin B12 ampoule of Iranian Hormone Pharmaceuticals was selected as the real sample. High recoveries of the analysis these real samples prove the applicability of this method.

Graphical Abstract

Fast and simple measurement of vitamin B12 by using nitrogen and sulfur co doped carbon quantum dots

Keywords

References

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Iranian Journal of Chemistry
Volume 3, Issue 2 - Serial Number 5
March 2021
Pages 177-185

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History

  • Receive Date: 08 November 2019
  • Revise Date: 07 March 2020
  • Accept Date: 16 April 2021

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