Vitamin A: An efficient and eco-friendly catalyst for the one-pot synthesis of pyrazolopyranopyrimidine and dihydropyrano[2,3-c]pyrazole derivatives

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran

2 Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.

3 Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran

4 Faculty of Sciences, Velayat University, Iranshahr, Iran

10.22036/cr.2022.334816.1177

Abstract

In this work, one-pot synthesis of dihydropyrano[2,3-c]pyrazole and pyrazolopyranopyrimidine derivatives from the reaction between aromatic aldehydes, ethyl acetoacetate, hydrazine hydrate, and malononitrile or barbituric acid in the presence of vitamin A as a heterogeneous, green and eco-friendly catalyst is discussed. mild reaction conditions, avoiding the use of any hazardous and toxic solvents, high yield, operational simplicity, simple work up without need to column chromatography are some of benefits present method in synthesis of this biologically compounds.
In this work, one-pot synthesis of dihydropyrano[2,3-c]pyrazole and pyrazolopyranopyrimidine derivatives from the reaction between aromatic aldehydes, ethyl acetoacetate, hydrazine hydrate, and malononitrile or barbituric acid in the presence of vitamin A as a heterogeneous, green and eco-friendly catalyst is discussed. mild reaction conditions, avoiding the use of any hazardous and toxic solvents, high yield, operational simplicity, simple work up without need to column chromatography are some of benefits present method in synthesis of this biologically compounds.

Graphical Abstract

Vitamin A: An efficient and eco-friendly catalyst for the one-pot synthesis of pyrazolopyranopyrimidine and dihydropyrano[2,3-c]pyrazole derivatives

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References

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History

  • Receive Date: 28 March 2022
  • Revise Date: 27 June 2022
  • Accept Date: 21 July 2022

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