نوع مقاله : مقاله پژوهشی
چکیده تصویری
موضوعات
عنوان مقاله English
نویسندگان English
This investigation presents the successful synthesis of a thermo-responsive polymer nanocomposite designed for the controlled absorption and release of dopamine. The nanocomposite features a layer comprising poly-N-isopropylacrylamide (PNIPAM) on modified graphene oxide (GO) nanosheets. PNIPAM, known for its temperature sensitivity, plays a pivotal role here in facilitating dopamine (DA) drug delivery. The modification of GO involves a two-step process incorporating trihydroxymethylaminomethane and acryloyl chloride, introducing an acrylate functional group on its surface. In the next step, the PNIPAM was polymerized through molecular imprinting method in the presence of dopamine, achieved via radical polymerization on functionalized GO nanosheets. After dopamine removal, a molecular imprinted polymer on GO sheets (GO@DA-MIP) was obtained. The synthesized nanocomposite was identified by FT-IR, SEM and XRD analyses. The investigation continued by studying the kinetics and isotherm of drug absorption by the nanocomposite and drug release in different temperatures and pHs. The participation of GO@DA-MIP in the absorption of dopamine in the presence of the analogue of this drug was also investigated. The overall results showed the thermo-responsiveness in GO@DA-MIP according to the purpose of dopamine drug delivery and the facilitating effect of pH on the release of this drug.
کلیدواژهها English
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