نوع مقاله : مقاله پژوهشی
عنوان مقاله English
نویسندگان English
Today, design and the synthesis of new drug delivery systems with multifunctional applications in various biomedical fields, such as cancer and microbial treatments, are widely considered by pharmaceutical companies and universities from all over the world. In this work, for the first time novel hybrid bionanocomposite hydrogels were fabricated via supramolecular interactions between carboxy methyl cellulose (CMC) and octa-aminopropyl polyhedral oligomeric silsesquioxane hydrochloride salt nanoparticles (OAPOSS NPs). Various spectroscopic analyses such as FTIR, TEM, TGA and FE-SEM were used to confirm the samples successful preparation. Drug loading and release properties of the synthesized bionanocomposite hydrogels were investigated using sunitinib malate (STM), a standard anticancer model drug, in neutral and acidic conditions. On the other hand, after 72 h, 59 and 28 % of the drug was released in acidic and neutral medium, respectively. The STM release mechanism was studied using Korsmeyer-Peppas and Higuchi kinetic models. Furthermore, the in-vitro antibacterial tests were carried out against both bacteria S. aureus to prove the effectiveness of synthesized samples as multifunctional carrier systems for biomedical applications.
کلیدواژهها English
